It is not new information that boys are more likely to have Autism Spectrum Disorder, they are in fact 5 times more likely to have it that girls are. Not until this year has it been fully understood why this is though.

Autism Gender Study

A study published in the American Journal of Human Genetics on Feb 27, 2014 helps explain why men are so much more likely to have a form of Autism Spectrum Disorder.

The findings indicated that girls were more resilient to genetic abnormalities than boys were. When girls are diagnosed with Autism Spectrum Disorder , they are more likely to have extreme genetic mutations than boys who show similar symptoms.

Author of the study Sebastien Jacquemont, an assistant professor of genetic medicine at the University Hospital of Lausanne, Switzerland says “Girls tolerate neurodevelopmental mutations more than boys do. This is really what the study shows.” Elaborating with “To push a girl over the threshold for Autism or any of these neurodevelopmental disorders, it takes more of these mutations. Its about resilience to genetic insult.”

Swiss researchers collaborated with the University of Washington School of Medicine to look at and analyze 16,000 DNA samples of people with neurodevelopmental disorders, including Autism Spectrum Disorder (ASD). Also analyzing genetic data from approximately 800 families affected by Autism.

The findings showed that girls diagnosed with a neurodevelopmental disorder (Autism Spectrum Disorder, Attention-deficit / Hyperactivity Disorder) had more harmful Copy-Number Variants (CNV’s) as well as more harmful Single-Nucleotide Variants (SNV’s) than boys diagnosed with the same disorder.

Benefits for Autism Treatment

While the researchers admit there are no immediate benefits from these findings, this knowledge will help direct future neurodevelopmental disorder research.

Andrew Adesman, M.D. and Chief Developmental and Behavioral Pediatrics at Steven & Alexandra Cohen Children’s Medical Center of New York noted that this new research reinforces that genetic differences or vulnerabilities are not limited to sex chromosomes.

Adesman explains that “Women seem to be a little more resilient in terms of being able to have minor abnormalities without having a developmental problem.”

This research helps explain why boys are far more likely to have a neurodevelopmental disorder and will help guide future research regarding Autism, ADD, ADHD and other similar disorders.

The study also helps explain why Glutathione benefits those with ASD. It helps protect and repair DNA and prevent mitochondrial dysfunction, helping minimize genetic defects and improving behavioral symptoms.

Full Article — Autism Gender Study

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Sources:

Sebastien Jacquemont, M.D., assistant professor, genetic medicine, University Hospital of Lausanne, Switzerland; Andrew Adesman, M.D., chief, developmental and behavioral pediatrics, Steven & Alexandra Cohen Children’s Medical Center of New York, New Hyde Park, N.Y.; Feb. 27, 2014, American Journal of Human Genetics