METTLER TOLEDO's new white paper explores four case studies where in situ monitoring helped researchers gain qualitative reaction information not offered by offline sampling techniques. This robust feedback enabled faster optimization, enhanced output and increased safety, each of which can help promote significant cost-savings.

METTLER TOLEDO has published another informative installment in its Recent Advances in Organic Chemistry white paper series. The free download, entitled "In Situ Monitoring of Chemical Reactions A Molecular Video," reviews four recent case studies where sophisticated in-line monitoring techniques provided helpful chemical reaction insight. The information gained helped researchers to accurately characterize reactions, optimize processes, and speed results, essentially helping them to "do more with less" a common theme in today's competitive chemical development laboratories.

Reviewed case studies document how inline monitoring using mid-infrared (mid-IR) technology differs from offline sampling techniques such as High Performance Liquid Chromatography(HPLC). Each covers a distinct experiment type including successful bimetallic catalyst use and one-step oxidative bond separation, and helps show how advanced in situ spectroscopy, and the resulting molecular video it provides, offers critical insight into complex reaction mechanisms, kinetics and pathways. This insight allowed quick characterization of each reaction type for timely optimization, better batch consistency and enhanced operator safety, especially during high-pressure, high-temperature experiments.

Other explored advantages of in-line monitoring-represented in reviewed examples by METTLER TOLEDO's React IR included an ability to monitor bubbles and solids, which enabled robust information capture during complex catalysis and hydrogenation. Sensitivity to water absorption bands promoted accurate characterization in aqueous environments as well. Finally, an ability to characterize reactions without sampling allowed observation of the chemistry in its natural environment, keeping reactant concentrations constant, avoiding phenomena such as quenching, and allowing both qualitative and quantitative data collection, depending on the experiment's goal. These and other advantages are helping to broaden academic and manufacturing use of in situ monitoring in labs around the world.

For a detailed look at representative experiments, and a more thorough review of how in situ monitoring is helping to enable more cost-effective academic research and manufacturing, download the white paper free at

About Mettler Toledo:
METTLER TOLEDO specializes in the area of precision instruments for professional use. METTLER TOLEDO laboratory instruments are used in research, scientific, drug discovery, and quality control labs, amongst many others in the pharmaceutical, chemical, food and cosmetics industries. METTLER TOLEDO comprehensive industrial solutions cover the various steps in a host of manufacturing processes at many of the same customers that laboratory serves. Solutions range from receiving raw materials through various manufacturing processes, in-line process control and end-of-line packaging control, to logistics and shipping. Increasingly, these solutions are fully integrated into the customer's IT environment, helping automate their workflows. In food retail, our offering for fresh food management ranges from receiving and pre-packaging, to in-store solutions for self-service departments, deli counters, and checkout terminals.

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